Dive deeper hero image

There is more to discover about UTI

Several challenges can hinder successful management of UTI, including challenges in diagnosing UTI, patient-related factors, and the risk of antimicrobial resistance.1,2 Make sure to consider all possibilities when evaluating patients with symptoms of UTI.

Treatment failure to empiric therapy is estimated to
be 12-17% in women with uncomplicated urinary tract infections (uUTI).*,3,4

Refresh your UTI knowledge

Dive deeper hero image

There is more to discover about UTI

Several challenges can hinder successful management of UTI, including challenges in diagnosing UTI, patient-related factors, and the risk of antimicrobial resistance.1,2 Make sure to consider all possibilities when evaluating patients with symptoms of UTI.

Treatment failure to empiric therapy is estimated to
be 12-17% in women with uncomplicated urinary tract infections (uUTI).*,3,4

Refresh your UTI knowledge

Dive deeper hero image

Treatment failure was evaluated in 2 US retrospective studies of >600K female outpatients treated empirically with an oral antibiotic for uUTI. Treatment failure was defined as any of the following occurring ≤28 days after the initial antibiotic was prescribed: a second oral antibiotic prescription, administration of an intravenous antibiotic, or a primary diagnosis of acute UTI in an emergency room or inpatient setting.3,4

Discover more about UTI

  • Show video transcript

    00:00:00 - 00:01:23

    ONSCREEN TEXT:

    DIVE DEEPER

    ONSCREEN TEXT:

    Urinary Tract Infections=UTIs

    There is more to discover about UTIs

    NARRATOR:

    Urinary tract infections, or UTIs, are common.
    But there is more to discover about UTI. Let’s refresh our knowledge.

    ONSCREEN TEXT:

    Treatment failure to empiric therapy is estimated to occur in 12%-17% of women with uncomplicated UTI*

    *2 retrospective cohort studies evaluated oral antibiotic treatment failure in US patients with uUTI. Treatment failure was defined as any of the following occurring ≤28 days after the date of empiric antibiotic therapy for uUTI: a second oral antibiotic prescription, administration of intravenous antibiotic, or a primary diagnosis of acute UTI in the emergency room or inpatient setting.

    NARRATOR:

    Treatment failure to empiric therapy is estimated to occur in about 12 to 17% of women with uncomplicated UTI.

    ONSCREEN TEXT:

    Several challenges can hinder successful management of UTI, including:

    Challenges in diagnosing UTI

    Risk of antimicrobial resistance

    NARRATOR:

    Several challenges can hinder successful management of UTI, including challenges in diagnosing UTI and the risk of antimicrobial resistance.

    ONSCREEN TEXT:

    Make sure to consider all possibilities when evaluating patients with symptoms of UTI.

    NARRATOR:

    Make sure to consider all possibilities when evaluating patients with symptoms of UTI.

    ONSCREEN TEXT:

    DEEPEN YOUR UTI KNOWLEDGE

    NARRATOR:

    When you deepen your UTI knowledge, what you discover may surprise you. For example…

    ONSCREEN TEXT:

    uUTI*
    Non-specific symptoms

    *uUTIs, also referred to as acute cystitis, are limited to the bladder and are not accompanied by systemic signs or symptoms seen in pyelonephritis.

    NARRATOR:

    …the symptoms that occur with uncomplicated UTI are non-specific and may overlap with other conditions and numerous risk factors hinder successful management of UTI. The physical and emotional impact of uncomplicated UTI can disrupt your patients’ lives.

    ONSCREEN TEXT:

    uUTI*
    Non-specific symptoms
    Risk factors can hinder successful management

    *uUTIs, also referred to as acute cystitis, are limited to the bladder and are not accompanied by systemic signs or symptoms seen in pyelonephritis.

    NARRATOR:

    …and numerous risk factors hinder successful management of UTI.

    ONSCREEN TEXT:

    uUTI*
    Non-specific symptoms
    Risk factors can hinder successful management
    Disrupt patients’ lives

    *uUTIs, also referred to as acute cystitis, are limited to the bladder and are not accompanied by systemic signs or symptoms seen in pyelonephritis.

    NARRATOR:

    The physical and emotional impact of uncomplicated UTI can disrupt your patients’ lives.

    ONSCREEN TEXT:

    DISCOVER MORE

    NARRATOR:

    Discover more, so you can help your patients with uncomplicated UTI.

    ONSCREEN TEXT:

    More To UTI

    NARRATOR:

    There may be more to UTI than you think.

    ONSCREEN TEXT:

    1. Hooton TM. Uncomplicated urinary tract infection. N Engl J Med. 2012;366(11): 1028-1037. 2. Kaye KS, Gupta V, Mulgirigama A, et al. Antimicrobial resistance trends in urine Escherichia coli isolates from adult and adolescent females in the United States from 2011 to 2019: rising ESBL strains and impact on patient management. Clin Infect Dis. 2021;73(11):1992-1999. 3. Franklin M, Sacks N, Emden M, et al. Healthcare resource use and costs associated with oral antibiotic treatment failure in uncomplicated urinary tract infection in the US [Poster EE548]. ISPOR 2023; May 7-10, 2023; Boston, MA.
4. Fromer DL, Luck ME, Cheng WY, et al. Incidence of treatment failure when treated with empiric oral antibiotics among US female outpatients with uncomplicated urinary tract infection. Poster 2828. Presented at IDWeek 2023; October 11-15, 2023; Boston, MA. 5. Trautner BW, Kaye KS, Gupta V, et al. Risk factors associated with antimicrobial resistance and adverse short-term health outcomes among adult and adolescent female outpatients with uncomplicated urinary tract infection. Open Forum Infect Dis. 2022;9(12):ofac623. 
6. Gupta K, Hooton TM, Naber KG, et al. International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: A 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases. Clin Infect Dis. 2011;52(5):e103-e120. 7. Brubaker L, Carberry C, Nardos R, Carter-Brooks C, Lowder JL. American Urogynecologic Society Best-Practice Statement: Recurrent Urinary Tract Infection in Adult Women. Female Pelvic Med Reconstr Surg. 2018;24(5):321-335. 8. Wesolek JL, Wu JY, Smalley CM, Wang L, Campbell MJ. Risk factors for trimethoprim and sulfamethoxazole-resistant Escherichia coli in ED patients with urinary tract infections. Am J Emerg Med. 2022;56:178-182. 9. Thompson J, Marijam A, Mitrani-Gold FS, Wright J, Joshi AV. Activity impairment, health-related quality of life, productivity, and self-reported resource use and associated costs of uncomplicated urinary tract infection among women in the United States. PLoS One. 2023;18(2):e0277728. 
10. Grigoryan L, Mulgirigama A, Powell M, Schmiemann G. The emotional impact of urinary tract infections in women: a qualitative analysis. BMC Women’s Health. 2022;22(1):182.

    
11. Uncomplicated urinary tract infections: developing drugs for treatment guidance for industry. Center for Drug Evaluation and Research. August 2019. Accessed August 14, 2023. https://www.fda.gov/regulatory-information/search-fda-guidance-documents/uncomplicated-urinary-tract-infections-developing-drugs-treatment-guidance-industry 12. Complicated urinary tract infections: developing drugs for treatment. Center for Drug Evaluation and Research. June 2018. Accessed August 14, 2023. https://www.fda.gov/regulatory-information/search-fda-guidance-documents/complicated-urinary-tract-infections-developing-drugs-treatment

    13. Anger J, Lee U, Ackerman LA, et al. Recurrent uncomplicated urinary tract infections in women: AUA/CUA/SUFU Guideline. American Urological Association. Published 2019. Updated 2022. Accessed April 2, 2023. https://www.auanet.org/guidelines-and-quality/guidelines/recurrent-uti

    For US healthcare professionals.
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    ©2023 GSK or licensor.
    IDUVID230004 September 2023
    Produced in USA.

Deepen your UTI knowledge. What you discover may surprise you

Bladder icon test
The symptoms that occur with uncomplicated UTI (uUTI)† are non-specific and may overlap with other conditions1

EXPLORE DIFFERENTIAL DIAGNOSES

Risk factors icon
Numerous factors can hinder successful management of UTI2,5-8

DISCOVER THE CHALLENGES

Impact on well being icon
The physical and emotional impact of uUTI† can disrupt your
patients’ lives9,10

UNDERSTAND PATIENT BURDEN

uUTIs, also referred to as acute cystitis, are limited to the bladder and are not accompanied by systemic signs or symptoms seen in pyelonephritis or urosepsis.11

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Refresh your knowledge with the facts below

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Bacteria image

Refresh your UTI knowledge

  1. Hooton TM. Uncomplicated urinary tract infection. N Engl J Med. 2012;366(11):1028-1037.
  2. Kaye KS, Gupta V, Mulgirigama A, et al. Antimicrobial resistance trends in urine Escherichia coli isolates from adult and adolescent females in the United States from 2011 to 2019: rising ESBL strains and impact on patient management. Clin Infect Dis. 2021;73(11):1992-1999.
  3. Franklin M, Sacks N, Emden M, et al. Healthcare resource use and costs associated with oral antibiotic treatment failure in uncomplicated urinary tract infection in the US [Poster EE548]. ISPOR 2023; May 7-10, 2023; Boston, MA.
  4. Fromer DL, Luck ME, Cheng WY, et al. Incidence of treatment failure when treated with empiric oral antibiotics among US female outpatients with uncomplicated urinary tract infection. Poster 2828. Presented at IDWeek 2023; October 11-15, 2023; Boston, MA.
  5. Trautner BW, Kaye KS, Gupta V, et al. Risk factors associated with antimicrobial resistance and adverse short-term health outcomes among adult and adolescent female outpatients with uncomplicated urinary tract infection. Open Forum Infect Dis. 2022;9(12):ofac623.
  6. Gupta K, Hooton TM, Naber KG, et al. International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: A 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases. Clin Infect Dis. 2011;52(5):e103-e120.
  7. Brubaker L, Carberry C, Nardos R, Carter-Brooks C, Lowder JL. American Urogynecologic Society Best-Practice Statement: Recurrent Urinary Tract Infection in Adult Women. Female Pelvic Med Reconstr Surg. 2018;24(5):321-335.
  8. Wesolek JL, Wu JY, Smalley CM, Wang L, Campbell MJ. Risk factors for trimethoprim and sulfamethoxazole-resistant Escherichia coli in ED patients with urinary tract infections. Am J Emerg Med. 2022;56:178-182.
  9. Thompson J, Marijam A, Mitrani-Gold FS, Wright J, Joshi AV. Activity impairment, health-related quality of life, productivity, and self-reported resource use and associated costs of uncomplicated urinary tract infection among women in the United States. PLoS One. 2023;18(2):e0277728.
  10. Grigoryan L, Mulgirigama A, Powell M, Schmiemann G. The emotional impact of urinary tract infections in women: a qualitative analysis. BMC Women's Health. 2022;22(1):182.
  11. Uncomplicated urinary tract infections: developing drugs for treatment guidance for industry. Center for Drug Evaluation and Research. August 2019. Accessed August 14, 2023. https://www.fda.gov/regulatory-information/search-fda-guidance-documents/uncomplicated-urinary-tract-infections-developing-drugs-treatment-guidance-industry
  12. Complicated urinary tract infections: developing drugs for treatment. Center for Drug Evaluation and Research. June 2018. Accessed August 14, 2023. https://www.fda.gov/regulatory-information/search-fda-guidance-documents/complicated-urinary-tract-infections-developing-drugs-treatment
  13. Anger J, Lee U, Ackerman LA, et al. Recurrent uncomplicated urinary tract infections in women: AUA/CUA/SUFU Guideline. American Urological Association. Published 2019. Updated 2022. Accessed April 2, 2023. https://www.auanet.org/guidelines-and-quality/guidelines/recurrent-uti